Prurigo nodularis
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U rezultatima Stiftung Warentest-a za 2022. iz Njemačke, zadovoljstvo potrošača ModelDerm-om bilo je samo nešto niže nego s plaćenim telemedicinskim konsultacijama.
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ReferencesPrurigo nodularis je dugotrajno stanje kože koje karakterišu višestruke čvrste kvržice i čvorovi, najčešće na vanjskim dijelovima ruku i nogu. Ove kvržice mogu varirati u boji od mesnatog do ružičastog i jako svrbe. Može zahvatiti ljude bilo koje dobi, a često su povezane s drugim kožnim stanjima koja uzrokuju kronični svrab, poput atopijskog dermatitisa. Opcije liječenja uključuju jake lijekove protiv svraba, lijekove koji utiču na imuni sistem i lijekove koji ciljaju nervni sistem. Liječenje nodularnog pruriga obično podrazumijeva dugotrajnu terapiju.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Liječenje obično uključuje korištenje krema ili injekcija steroida na zahvaćeno područje. U težim ili tvrdoglavim slučajevima mogu biti potrebni tretmani poput svjetlosne terapije ili lijekova koji potiskuju imuni sistem. Talidomid i lenalidomid su opcije za teške slučajeve, ali mogu imati ozbiljne nuspojave. Noviji tretmani (opioid receptor antagonists, neurokinin-1 receptor antagonists) obećavaju bolje rezultate u liječenju prurigo nodularisa, s manje nuspojava u usporedbi s talidomidom ili lenalidomidom.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo je stanje kože koje karakteriše dugotrajan svrab (koji traje više od 6 nedelja), lezije kože povezane s ogrebotinama i istorija čestog češanja. Uključuje neuroinflamaciju i fibrozu kože.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis je dugotrajan problem kože, obeležen čvorićima koji svrbe. Ne znamo tačno šta ga uzrokuje, ali čini se da imunološki i neurološki problemi igraju ulogu u ciklusu svraba i grebanja. Trenutno ne postoji nijedan tretman odobren od strane američke FDA posebno za Prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ Liječenje ― OTC lijekovi
Pranje zahvaćenog područja sapunom ne pomaže i može pogoršati stanje. OTC steriodne masti mogu pomoći u ublažavanju simptoma, ali obično ih je potrebno primjenjivati nekoliko sedmica da bi se postiglo poboljšanje. Nastavak uzimanja antihistaminika također pomaže u ublažavanju svraba.
#OTC steroid ointment
#OTC antihistamine
○ Treatment
#Intralesional triamcinolone injection